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           A Therapeutic Challenge  Microbial Keratitis following Collagen Cross Linkage in a case of advance Keratoconus A case report 
           1 .Jaya Kaushik¹ 
            2. Jitendra Kumar Singh Parihar² 
            3. Devender Paul Vats³ 
            4. Hemant Singh Trehan4 
            5. Shantanu Mukherji5 
            6. Pramod Guleria6 
                      Affiliation: 
            Authors no 1,2,4 ,5 and 6: 1,2,3,5, and 6     Army Hospital (Research & Referral), New Delhi, India 
            Author no 3: Affiliation: 6 Armed Forces Medical College Pune, India 
                      Purpose:  To analyses  an unusual occurrence and subsequent strategies of  management and visual rehabilitation  of uniocular infectious keratitis  following bilateral C3R with UVA treatment in a case of  progressive keratoconus. 
                      Methods: Pre C3R  status revealed  best corrected visual acuity of    6/12 with - 4 Dsph and -3.00 D Cyl @  75 degree in Right eye and  -3.50 Sph and -5.00 DCyl @115 degree in left eye. Slit lamp  confirmed Keratoconus.  Thinnest cornea was  400 & 416 micron .Orbscan  proved progressive Keratoconus in both eyes. Bilateral corneal collagen cross linking with riboflavin  was performed under strict aseptic conditions in the OT.  
                      Results: The first  day mild swelling in both upper eye lids with conjunctival congestion  was visible. Yet cornea was clear with debrided epithelium and BCL in situ. Marked circumciliary congestion and  subepithelial haze with superficial 2 to 3 stromal infiltrates and  stromal oedema  on next day  confirmed  infective keratitis. Superficial corneal scraping was done, BCL and riboflavin drops sent for microbial before starting antimicrobial. The infiltrates and  stromal oedema resolved and subepithelial haze  gradually decreased. Microbial keratitis did not influence the course of CXL treatment. Significant improvement  in astigmatism, BCVA  and maximum simulated keratometry values was observed  at 6 months interval. However residual nebular grade opacity remained there. 
                      Conclusion: Though the CXL procedure is simple and safe, the unusual  infections  may  lead to  compromised  visual acuity. The use of BCL may increase the risk of infection. Hence a meticulous approach should be followed.  
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